Research Focus
Our research focuses on studying the biological functions of hydrogen sulfide, a gaseous signaling molecule that is naturally synthesized by the body in small amounts. Hydrogen sulfide plays a key role in maintaining cellular redox balance and influences various physiological processes. Disturbed hydrogen sulfide homeostasis is commonly associated with the onset and progression of many non-communicable diseases, which often share a common denominator – unhealthy lifestyle habits. In this context, we examine how unbalanced diets rich in fats and carbohydrates, as well as metabolic diseases such as obesity and diabetes, affect hydrogen sulfide production and its effects in the body. We are also investigating the importance of other sulfur-containing compounds, such as the amino acid cysteine, a precursor for the synthesis of both hydrogen sulfide and the major cellular antioxidant glutathione. We study how these molecules contribute to the regulation of oxidative stress, a hallmark of many metabolic diseases. In particular, our research focuses on the role of mitochondria, which are not only the main energy centers of the cell, but also the producer of reactive oxygen species and the site of hydrogen sulfide oxidation.
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Head of the Research Group
Dr. Lenka Tomášová specializes in experimental research focused on the role of endogenous sulfur species in the regulation of physiological processes in the body. She investigates the molecular mechanisms by which these molecules mediate antioxidant defense and help prevent the development of cardiometabolic disorders.
Employees
| Title | Name | Phone | ORCID | |
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| Mgr., PhD. | 02/ 3229 5323 |
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| Mgr., PhD. | 02/ 3229 5320 |
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| RNDr., DrSc. | 02/ 3229 5319 |
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| Ing. | 02/ 3229 5318 | |||
| Ing. | 02/ 3229 5318 |
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| Mgr., PhD. | 02/ 3229 5323 |
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