Research Topic
Topic 1
Investigation of bioactive properties of newly discovered agonists of nuclear retinoid X receptors (RXRs), which upon binding to RXR molecules may affect a variety of cellular processes and endocrine functions
- To explore molecular mechanisms of antitumor properties of novel RXR ligands, trialkyl/triaryltin isothiocyanates and carboxylates, and biologically active 4-pyranones in hormone-related cancer cell lines (mammary, thyroid, gonadal, neuronal)
- To examine endocrine-disrupting properties of trialkyl/triaryltin isothiocyanates and carboxylates with focus on reproductive system (primary and tumour gonadal cells)
Topic 2
Monitoring the effects of different endocrine disruptors (EDC) in regulation of reproductive processes and hormone-related cancers using a battery of in vitro tests
- To study the effects of biologically relevant mixtures of EDCs (persistent and non-persistent compounds) on ovarian intrafollicular processes
- To investigate reproductive toxicity and neurotoxicity of metal and metal oxide nanoparticles using in vitro model systems
Head of the Research Group
Dr. Július Brtko is an internationally recognized scientist, the founder and leader of a significant research direction in Slovakia – elucidation of the role, function and properties of hormone-inducible transcription factors in the organism. A part of his creative capacity was devoted to kojic acid derivatization and the study of the biological properties of its novel derivatives. He is an author and co-author of 16 patents and scientific papers in leading international scientific journals.
Employees
| Title | Name | Phone | ORCID | |
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| Ing. | ||||
| Ing., DrSc. | 02/ 32295 kl. 277 |
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| Mgr., PhD. | 02/ 32295 kl. 275, 274, 283, 286 | |||
| Mgr., PhD. | 02/ 32295 kl. 276, 283, 286 |
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| Ing., PhD. | 02/ 32295 kl. 276, 283, 286 | |||
| Mgr., CSc. | 02/ 32295 kl. 900, 274, 283 |
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| 02/ 32295 kl. 274 |