Tumor Immunology

Research Topic

The research group Tumor Immunology is devoted to the study of mechanisms of development and progression of hematological B-cell malignancies, especially multiple myeloma and lymphomas, in order to develop targeted therapy for the elimination of cancer.

Our current research focus around multiple aspects of translational hematological research:

• Study of clonal heterogeneity during development and progression of multiple myeloma.
• Large-scale genomic and proteomic profiling in Waldenström Macroglobulinemia (WM) and multiple myeloma.
• Mechanisms of evolution from precursor premalignant stages (MGUS, smoldering MM and smoldering WM) to active malignant disease.
• Role of the tumor microenvironment in regulation of clonal selection and progression of multiple myeloma.
• Tumor-stromal-immune cell interactions in the tumorsuppressive niche of the tumor microenvironment during development and progression of tumor.
• Preparation of the metastatic niche for tumor colonization.
• Role of the tumor microenvironment in regulation of drug resistance.
• Role of circulating tumor cells and mechanisms of cell dissemination (metastasis regulation) in progression of B-cell neoplasms.
• Role of exosomes in cancer progression.
• Use of nanoparticles in the treatment of cancer.
• Effect of chemo- and/or immuno-therapies on intraclonal selection in hematological malignancies.
• Validation and determination of novel chemo- and immunotherapeutic strategies.

Head of the Research Group

Employees

Title	Name	E-mail	Phone	ORCID
Mgr., PhD.	Csicsátková Nikoleta
MSc.	Dická Barbora
BSc., PhD.	Gogová Rebeca
Mgr.	Grofová Gabriela
Mgr.	Hučko Milan
RNDr., PhD.	Cholujová Dana		02/ 3229 5159
RNDr., PhD.	Jakubíková Jana		02/ 3229 5158
Mgr.	Marinkovičová Mária Elisabeth		02/3229 5151
Mgr., PhD.	Rausová Zuzana
RNDr., DrSc.	Sedlák Ján		02/3229 5152
Mgr.	Strížová Anna
Mgr.	Suroviaková Katarína
Mgr.	Tomášová Lucia
Mgr.	Valušková Zuzana		02/ 3229 5165