Projects

International research grants:

Multiple myeloma intra-clonal heterogeneity: evolution and implications of targeted therapy (ERA-NET: Aligning national/regional translational cancer research programmes and activities TRANSCAN-2 collaborative EU; 2016-2019, J. Jakubikova (coordinator&PI))

Clonal architecture in development of MM and therapy induced intra-clonal heterogeneity in MM progression (Marie Curie Reintegration grant EU; 2015-2018, J. Jakubikova (PI))

National research grants:

Bacterial Lon protease as an emerging tool for multiple myeloma
treatment (APVV; 2022-2026, J. Jakubikova (co-PI))

Cancer immunoediting in multiple myeloma: immune checkpoints and clinical significance (APVV; 20210-2025, J. Jakubikova (PI))

Anti-myeloma activity by composite nanomaterials and its mechanism in vitro and in vivo (VEGA; 2020-2022, J. Jakubikova (PI))

Assessment of immune checkpoints in B cell malignancies (VEGA; 2020-2022, D. Cholujova (PI))

Preparation of new antibiotics and antitumor agents by manipulations of secondary metabolite genes and synthetic biology methods (APVV; 2020-2024, J. Jakubikova (co-PI))

Development of novel diagnostic and predictive high-dimensional immunophenotyping tool for hematological malignancies (Ministry of Health grant 2019/14-BMCSAV-9; 2019-2022, J. Jakubikova (PI))

Harnessing the immunological mechanisms in various subtypes of B cell lymphoma (APVV; 2020-2024, D. Cholujova (PI))

Tumor heterogeneity in multiple myeloma: evolution and clinical significance (APVV; 2017-2021, J. Jakubikova (PI))

Mechanism of anti-tumor activity of realgar nanoparticles and its synergism with anti-myeloma agents (VEGA; 2017-2019, J. Jakubikova J (PI))

The impact of tumor microenvironment and therapy on subclonal diversity in MM and WM (VEGA; 2017-2019, D. Cholujová D (PI))

Prognostic biomarker for colorectal carcinoma based on miRNA analysis and characterization of selected proteins in the circadian context (APVV, 2015-2019, J. Sedlak J (PI))